Conclusion I

Conclusion II

Conclusion III

Conclusion IV

Final Conclusions

1.

INTRODUCTION

1.1

Scrapie and Scrapie freedom

1.2

The objectives of this report

2.

THE DISEASE

2.1

General considerations

2.2

The clinical disease

2.3

The pathology and diagnosis

2.4

The cause

2.5

Strains of agents

2.6

Molecular strain typing

2.7

Pathogenesis

2.8

Transmission

2.9

Variation in host response to Scrapie

2.10

Is Scrapie an infectious or genetic disease?

2.11

Classification of Scrapie-like diseases

2.12

PrP

3.

ORIGIN OF SHEEP AND SHEEP PRODUCTION METHODS IN ARGENTINA

3.1

The origin of sheep in Argentina

3.2

Sheep production systems

4.

SURVEILLANCE FOR SCRAPIE

4.1

Awareness of clinical signs

4.2

Awareness programme for BSE and Scrapie

4.3

Surveillance

4.3.1

Passive surveillance

4.3.2

Active surveillance

4.4

Surveillance for Scrapie in Argentina - results

4.4.1

Clinical surveillance - indigenous sheep

4.4.2

Surveillance of imported sheep and genetic materials

4.4.3

Pathological examination of brains

4.4.3.1

Special training

4.4.3.2

Records and origin of cases

4.4.3.3

Laboratory examinations

4.4.4 PrP genotypes

4.5

Argentine goats, moufflon and Scrapie surveillance

4.5.1

Goats

4.5.2

Moufflon

4.6

Enforcement of the ban on feeding ruminant protein to ruminant animals

4.7 Surveillance for Creutzfeldt-Jakob disease (including v-CJD) in Argentina

5.

FUTURE AIMS

6.

CONCLUSIONS

6.1

OIE conditions for a Scrapie free country

6.2

ARTICLE 3.3.8.1. Statements supporting the case for Argentina

6.2.1

Keeping up to date with current knowledge and diagnostic methods

6.2.2.

High standards of Official Veterinary surveillance, reporting and control

6.2.3.

Clinical inspection, laboratory diagnosis and record keeping

6.3

ARTICLE 3.3.8.2., 1), 3) and 4), statements supporting the case for Argentina

6.3.1

Notification

6.3.2.

Absence of clinical cases

6.3.3

Continuous surveillance and monitoring

6.3.4.

Ruminant MBM Feed Ban

6.3.5.

Importation of sheep, goats, semen and embryos/ova

6.3.6.

ABSENCE OF BSE IN CATTLE IN ARGENTINA AND ABSENCE OF ANY ANIMAL TSE IN ARGENTINA

6.4

CONCLUSION I

6.5

ADDITIONAL ASSURANCES I

6.6

CONCLUSION II

6.7

ADDITIONAL ASSURANCES II

6.8

CONCLUSION III

7.

FINAL CONCLUSIONS

8.

REFERENCES

9.

GLOSSARY